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Immunological and virological characteristics of human immunodeficiency virus type 1 superinfection:

Yang Gao, Wen Tian, Xiaoxu Han, Feng Gao

Frontiers of Medicine 2017, Volume 11, Issue 4,   Pages 480-489 doi: 10.1007/s11684-017-0594-8

Abstract:

Superinfection is frequently detected among individuals infected by human immunodeficiency virus typeI (HIV-1).

Keywords： human immunodeficiency virus type I     superinfection     incidence     immune response    

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Molecular network-based intervention brings us closer to ending the HIV pandemic

Xiaoxu Han, Bin Zhao, Minghui An, Ping Zhong, Hong Shang

Frontiers of Medicine 2020, Volume 14, Issue 2,   Pages 136-148 doi: 10.1007/s11684-020-0756-y

Abstract: Precise identification of HIV transmission among populations is a key step in public health responses. However, the HIV transmission network is usually difficult to determine. HIV molecular networks can be determined by phylogenetic approach, genetic distance-based approach, and a combination of both approaches. These approaches are increasingly used to identify transmission networks among populations, reconstruct the history of HIV spread, monitor the dynamics of HIV transmission, guide targeted intervention on key subpopulations, and assess the effects of interventions. Simulation and retrospective studies have demonstrated that these molecular network-based interventions are more cost-effective than random or traditional interventions. However, we still need to address several challenges to improve the practice of molecular network-guided targeting interventions to finally end the HIV epidemic. The data remain limited or difficult to obtain, and more automatic real-time tools are required. In addition, molecular and social networks must be combined, and technical parameters and ethnic issues warrant further studies.

Keywords： human immunodeficiency virus type 1     molecular cluster     transmission cluster     risk network     targeted intervention    

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Natural history of HIV infection in former plasma donors in rural China

Min ZHANG, Hong SHANG, Zhe WANG, Wei-Guo CUI, Qing-Hai HU

Frontiers of Medicine 2010, Volume 4, Issue 3,   Pages 346-350 doi: 10.1007/s11684-010-0102-x

Abstract: FPDs all have an approximate time of human immunodeficiency virus (HIV) infection during the mid-1990s

Keywords： human immunodeficiency virus (HIV)     former plasma donor     natural history     China    

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Clinical significance of human papilloma virus infection in the cervical lesions

Shuang LI, Yu-Han MENG, Hu TING, Jian SHEN, Ding MA

Frontiers of Medicine 2010, Volume 4, Issue 3,   Pages 264-270 doi: 10.1007/s11684-010-0094-6

Abstract: Cervical cancer, related with human papilloma virus (HPV) infection, has been one of the severest diseases

Keywords： cervical lesion     high risk-human papilloma virus     persistent infection     loading dose     cervical intraepithelial    

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Universal influenza virus vaccines: what can we learn from the human immune response following exposure

Daniel Stadlbauer, Raffael Nachbagauer, Philip Meade, Florian Krammer

Frontiers of Medicine 2017, Volume 11, Issue 4,   Pages 471-479 doi: 10.1007/s11684-017-0602-z

Abstract:

Several universal influenza virus vaccine candidates based on eliciting antibodies against the hemagglutininSimilarly, the majority of human anti-stalk monoclonal antibodies that have been isolated are directedHere we review what is known about the human humoral immune response to vaccination and infection withunderstanding of this phenomenon and the underlying mechanisms might help to develop future universal influenza virus

Keywords： universal influenza virus vaccine     hemagglutinin stalk     H7N9    

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Metabolomics in human type 2 diabetes research

Jingyi Lu, Guoxiang Xie, Weiping Jia, Wei Jia

Frontiers of Medicine 2013, Volume 7, Issue 1,   Pages 4-13 doi: 10.1007/s11684-013-0248-4

Abstract: This review summarizes the current findings of metabolomic studies in human investigations with the mostcommon form of diabetes, type 2 diabetes.

Keywords： metabolomics     type 2 diabetes     metabolic pathway     mass spectrometry     nuclear magnetic resonance (NMR)    

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<i>RR1i> and <i>RR2i> gene deletion affects the immunogenicity of a live attenuated pseudorabiesvirus vaccine candidate in natural pig host

Shijun YAN,He YAN,Chaolin ZHANG,Tongyan WANG,Qingyuan YANG,Zhe SUN,Yan XIAO,Feifei TAN,Xiangdong LI,Kegong TIAN

Frontiers of Agricultural Science and Engineering 2016, Volume 3, Issue 1,   Pages 81-86 doi: 10.15302/J-FASE-2016088

Abstract: encode the small subunit and large subunit of viral ribonucleotide reductase (RR) in pseudorabies virusIn this study, we deleted and genes based on a / / triple gene-deleted pseudorabies virus and testedThe rescued virus showed similar growth properties and plaque size as its parent strain.In an animal study, the virus could elicit humoral immune responses shown by generation of gB-specificantibodies and virus neutralizing antibodies.

Keywords： pseudorabies virus     <i>RR1i> and <i>RR2i>     ribonucleotide reductase     vaccine candidate    

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Hyperthermia on skin immune system and its application in the treatment of human papillomavirus-infected

Xinghua Gao, Hongduo Chen

Frontiers of Medicine 2014, Volume 8, Issue 1,   Pages 1-5 doi: 10.1007/s11684-014-0309-3

Abstract: We conducted a series of open or controlled trials to treat skin human papillomavirus infection by inducing

Keywords： hyperthermia     HPV     immune response     virus     tumor    

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Epidemiological studies of women under age 30 infected with human papillomavirus

Zhihua LIU MD, Qing LI BM, Weihong LI BM,

Frontiers of Medicine 2009, Volume 3, Issue 4,   Pages 459-462 doi: 10.1007/s11684-009-0084-8

Abstract: The aim of this paper was to investigate the prevalence of human papilloma virus (HPV) infection in womenThe HPV positive rate was 247/2052 (12.00%), and 35/2052 (1.71%) of the cases were≥CIN I by pathologicalcases, including 39HPV-positive cases (13.40%) and one case of pathological diagnosis≥CIN Iage group, including 208 HPV-positive cases (11.81%) and 34 cases of pathological diagnosis≥CIN IFurthermore, 80.00% (28/35) cases of pathological diagnosis≥CIN I and 90.91% (10/11) lesions of

Keywords： cervical cancer     human papilloma virus     cervical intraepithelial neoplasia    

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An experimental characterization of human torso motion

Daniele CAFOLLA,I-Ming CHEN,Marco CECCARELLI

Frontiers of Mechanical Engineering 2015, Volume 10, Issue 4,   Pages 311-325 doi: 10.1007/s11465-015-0352-z

Abstract:

The torso plays an important role in the human-like operation of humanoids.In this paper, a method is proposed to analyze the behavior of the human torso by using inertial andExperiments are conducted to characterize the motion performance of the human torso during daily routineFurthermore, the forces acting on the human body during these operations are evaluated to design and

Keywords： experimental biomechanics     human torso     analysis     inertial sensor     characterization    

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Human monoclonal antibodies as candidate therapeutics against emerging viruses

Yujia Jin, Cheng Lei, Dan Hu, Dimiter S. Dimitrov, Tianlei Ying

Frontiers of Medicine 2017, Volume 11, Issue 4,   Pages 462-470 doi: 10.1007/s11684-017-0596-6

Abstract: syndrome coronavirus (SARS-CoV), Middle East respiratory syndrome coronavirus (MERS-CoV), and Ebola virusConsequently, an increasing number of mAbs, which exhibit high potency against emerging viruses <i>in vitroi> and in animal models of infection, have been developed.We also review the application of recently developed human mAbs against SARS-CoV, MERS-CoV, and Ebolavirus and discuss prospects for the development of mAbs as therapeutic agents against emerging viral

Keywords： human monoclonal antibodies     emerging infectious diseases     SARS-CoV     MERS-CoV     Ebola virus    

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Dysregulation of β-catenin by hepatitis B virus X protein in HBV-infected human hepatocellular carcinomas

Lei CHEN, Liang HU, Liang LI, Yuan LIU, Qian-Qian TU, Yan-Xin CHANG, He-Xin YAN, Meng-Chao WU, Hong-Yang WANG,

Frontiers of Medicine 2010, Volume 4, Issue 4,   Pages 399-411 doi: 10.1007/s11684-010-0170-y

Abstract: in the development of hepatocellular carcinoma (HCC), β-catenin was correlated with hepatitis B virusThe expression levels of wild-type β-catenin and E-cadherin were decreased in HepG2 cells expressinghepatitis B virus X protein (HBx), accompanied by destabilization of adherens junction.Reverse transcriptase PCR (RT-PCR), Northern and Western blot showed that reduction of wild-type βsuggest that the expression of HBx contributed to the development of HCC, in part, by repressing the wild-type

Keywords： hepatocellular carcinoma     hepatitis B virus X protein     β     -catenin     cell adhesion     E-cadherin     transcriptional    

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NRTIs’ effect on the sequence of mitochondrial DNA HV 2 in HIV infected patients

Ya-Song WU MD, PhD, Xin-Yue CHEN MD, Ying SHI PhD, Hao WU MD, De-Xi CHEN MD, PhD, Yu SUN MD, Fu-Jie ZHANG MD,

Frontiers of Medicine 2010, Volume 4, Issue 2,   Pages 177-184 doi: 10.1007/s11684-010-0038-1

Abstract: antiretroviral therapy (cART) has significantly improved the life expectancy of people living with humanimmunodeficiency virus (HIV), but it has many side effects such as lipodystrophy (LD), hepatic steatosisNucleoside reverse transcriptase inhibitors (NRTIs) could damage the mitochondria by inhibiting the human

Keywords： nucleoside reverse transcriptase inhibitors     human immunodeficiency virus     mitochondrial DNA     D loop     mutation    

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correction of hemorrhagic diathesis in hemophilia A mice by an AAV-delivered hybrid FVIII composed of the human

Frontiers of Medicine 2022, Volume 16, Issue 4,   Pages 584-595 doi: 10.1007/s11684-021-0844-7

Abstract: In this study, a recombinant FVIII cDNA encoding a human/rat hybrid FVIII with an enhanced procoagulantpotential for adeno-associated virus (AAV)-delivered gene therapy was developed.Plasmids containing human FVIII heavy chain (hHC), human light chain (hLC), and rat light chain (rLC)

Keywords： hemophilia A     adeno-associated virus (AAV)     human/rat hybrid factor VIII     gene therapy     dual chain strategy    

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A low cost wearable optical-based goniometer for human joint monitoring

Chee Kian LIM, Zhiqiang LUO, I-Ming CHEN, Song Huat YEO

Frontiers of Mechanical Engineering 2011, Volume 6, Issue 1,   Pages 13-22 doi: 10.1007/s11465-011-0201-7

Abstract: and occupational therapy, goniometers are indispensible when it comes to angular measurement of the humanIn this paper, we present a reliable and non-intrusive design of an optical-based goniometer for humanThis device will allow continuous and long-term monitoring of human joint motion in everyday setting.

Keywords： optical     goniometer     human-joint measurement    

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Title Author Date Type Operation

Immunological and virological characteristics of human immunodeficiency virus type 1 superinfection:

Yang Gao, Wen Tian, Xiaoxu Han, Feng Gao

Journal Article

Molecular network-based intervention brings us closer to ending the HIV pandemic

Xiaoxu Han, Bin Zhao, Minghui An, Ping Zhong, Hong Shang

Journal Article

Natural history of HIV infection in former plasma donors in rural China

Min ZHANG, Hong SHANG, Zhe WANG, Wei-Guo CUI, Qing-Hai HU

Journal Article

Clinical significance of human papilloma virus infection in the cervical lesions

Shuang LI, Yu-Han MENG, Hu TING, Jian SHEN, Ding MA

Journal Article

Universal influenza virus vaccines: what can we learn from the human immune response following exposure

Daniel Stadlbauer, Raffael Nachbagauer, Philip Meade, Florian Krammer

Journal Article

Metabolomics in human type 2 diabetes research

Jingyi Lu, Guoxiang Xie, Weiping Jia, Wei Jia

Journal Article

<i>RR1i> and <i>RR2i> gene deletion affects the immunogenicity of a live attenuated pseudorabiesvirus vaccine candidate in natural pig host

Shijun YAN,He YAN,Chaolin ZHANG,Tongyan WANG,Qingyuan YANG,Zhe SUN,Yan XIAO,Feifei TAN,Xiangdong LI,Kegong TIAN

Journal Article

Hyperthermia on skin immune system and its application in the treatment of human papillomavirus-infected

Xinghua Gao, Hongduo Chen

Journal Article

Epidemiological studies of women under age 30 infected with human papillomavirus

Zhihua LIU MD, Qing LI BM, Weihong LI BM,

Journal Article

An experimental characterization of human torso motion

Daniele CAFOLLA,I-Ming CHEN,Marco CECCARELLI

Journal Article

Human monoclonal antibodies as candidate therapeutics against emerging viruses

Yujia Jin, Cheng Lei, Dan Hu, Dimiter S. Dimitrov, Tianlei Ying

Journal Article

Dysregulation of β-catenin by hepatitis B virus X protein in HBV-infected human hepatocellular carcinomas

Lei CHEN, Liang HU, Liang LI, Yuan LIU, Qian-Qian TU, Yan-Xin CHANG, He-Xin YAN, Meng-Chao WU, Hong-Yang WANG,

Journal Article

NRTIs’ effect on the sequence of mitochondrial DNA HV 2 in HIV infected patients

Ya-Song WU MD, PhD, Xin-Yue CHEN MD, Ying SHI PhD, Hao WU MD, De-Xi CHEN MD, PhD, Yu SUN MD, Fu-Jie ZHANG MD,

Journal Article

correction of hemorrhagic diathesis in hemophilia A mice by an AAV-delivered hybrid FVIII composed of the human

Journal Article

A low cost wearable optical-based goniometer for human joint monitoring

Chee Kian LIM, Zhiqiang LUO, I-Ming CHEN, Song Huat YEO

Journal Article